20-23 september 2017. Pécs - Hungary
Cognitive control and cognitive flexibility: From behavioral, systems and neuronal mechanisms to clinical implications (Ales Stuchlik)
Cognitive control and cognitive flexibility: From behavioral, systems and neuronal mechanisms to clinical implications (Ales Stuchlik) 2017-09-21 - 11:00-13:00
Venue: Conference Room F08
The symposium will provide in-depth examination of the physiological and pathophysiological mechanisms of cognitive control and flexibility, processes that are impaired in many neuropsychiatric disorders, that cannot be adequately treated, yet majorly determine patient´s daily functioning.


Ales Stuchlik (Chair)
Institute of Physiology, Czech Academy of Sciences



11:00 – 11:24 Eduard Kelemen
National Institute of Mental Health, Klecany, Czech Republic
„Organizing distinct streams of information in activity of hippocampal cell assemblies”

11:24 – 11:48 Malgorzata Wesierska
Nencki Institute of Experimental Biology, Warsaw, Poland
The role of the retrosplenial cortex and hippocampus in navigation in dynamic environments

11:48 – 12:12 André Fenton
Neurobiology of Cognition Laboratory, Center for Neural Science, New York University, USA
„The microstructure of cognition-associated neural coordination and its discoordination in Fragile X mutant mice”

12:12 – 12:36 Ales Stuchlik (Chair)
Institute of Physiology Czech Academy of Sciences, Prague, Czech Republic
„Spatial memory and cognitive control and flexibility deficits in animal models of schizophrenia and obsessive-compulsive disorder”

12:36 – 13:00 Iveta Fajnerová  (Co-Chair)
National Institute of Mental Health, Klecany, Czech Republic
"Navigation in dynamic environments: Impairment of cognitive coordination and behavioral flexibility in schizophrenia and obsessive-compulsive disorder"



Cognitive control refers to the ability to select from multiple possibilities, the most relevant sensory stimuli and appropriate behavioral actions. In the abundance of available information, some important, some useless or distracting, it is most adaptive to attend to what is useful and ignore what is useless or distracting. Cognitive control is gaining attention among neuroscientists from diverse research areas for its important role in higher cognition, and also for its clinical relevance, because deficits in cognitive control are prevalent in diseases of thought, cognition and behavior. This diversity is represented in the symposium speakers. Eduard Kelemen will focus on dynamic grouping, the transient co-activation of neural subpopulations that represent the same information when multiple information streams are concurrently relevant. Dynamic grouping may be a neural mechanism of cognitive control in the rodent hippocampus. Malgorzata Wesierska studies the role of multiple brain systems. She will focus on the role of retrosplenial cortex in cognitive control of conflicting local and distal spatial information in rats. André Fenton will discuss the dynamical microstructure of dynamic grouping and other forms of neural coordination and their discoordination in a Fragile X mutant mouse model of autism. Ales Stuchlik will discuss impaired cognitive control and flexibility in animal models of schizophrenia and other neuropsychiatric disorders. Finally, Iveta Fajnerova will describe her work using virtual reality tasks, to identify specific cognitive deficits in mental flexibility, learning and memory in first episode schizophrenia patients.. The symposium will provide a comprehensive and contemporary discussion of cognitive control, its physiological mechanisms, and clinical importance.


This work was supported by GACR grant 17-04047S AZV grant 15-34524A, AZV grant 17-30833A and  GACR Center of Excellence P304/12/G069. Institutional support for IPHYS was provided by RVO: 67985823. Institutional support for NIMH-CZ was provided by the project “Sustainability for the National Institute of Mental Health”, under grant number LO1611, with a financial support from the Ministry of Education, Youth and Sports of the Czech Republic under the NPU I program.