The session presents recent advances in the fields of neuromodulatory systems and brain states focusing on their interaction during behavior and the neural mechanisms involved.
Institute of Experiemntal Medicine, Budapest, Hungary
Magor L. Lőrincz
University of Szeged, Szeged, Hungary
Team Motivation Brain & Behavior ICM, Paris, France
The role of noradrenaline and dopamine in the effort/reward trade off
Department of Neurology
University of Bern, Switzerland
Control of brain states by the lateral hypothalamus
Inserm UMR Paris, France
Role of central serotonin innervation from the dorsal raphe in the onset of maternal behavior
Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest, Hungary
State dependent control of medial septal GABAergic networks by the hippocampus
Magor L. Lőrincz
University of Szeged, Hungary
"Rapid, cell type specific control of raphe circuits by the lateral hypothalamus"
The internal state of an animal has large impact on neural processing and, consequentially, behavioral responses. Changes to brain state can occur at various timescales and have a marked influence on a wide range of brain functions including neuronal synchrony reflected in rhythmic population activity and sensory processing. The state dependent activity of various cortical and subcortical networks is controlled by spatially and temporally coordinated inter-areal and local interactions between neurochemically heterogeneous groups of neurons. Of particular interest in the control of brain states and associated synchronous rhythmic activities are inhibitory circuits capable of rapidly and transiently inactivating specific subsets of neurons and neuromodulatory systems acting on large groups of neurons in spatially distinct locations on multiple timescales. The objective of this symposium is to present novel research including a substantial fraction of unpublished results obtained in the field of neuromodulation and brain states. Specific topics will include the following.
- The state dependent role of hippocampo-septal feedback. In contrast to the large and rapidly growing amount of reports concerning the mechanisms that govern subcortical modulator action in cortical targets, surprisingly little is known about how the cortex influences its own modulator inputs. Varga will cover how the hippocampus controls its major modulatory input, the medial septum.
- The impact of feed-forward inhibitory lateral hypothalamic inputs to the thalamic reticular nucleus. Adamantidis will demonstrate the link between the activation of hypothalamic hypocretin/orexin or MCH neurons and arousal or REM sleep switch. He will also describe a new feedforward inhibitory arousal circuit that links the lateral hypothalamus to the reticular thalamus and thalamo-cortical loops.
- Synaptic mechanisms of oxytocin mediated changes in excitation/inhibition balance in the auditory cortex and its impact on sensory coding of salient stimuli during maternal behavior. Oxytocin is important for social interactions and maternal behavior. Froemke will discuss new and unpublished data on how oxytocin enables maternal behavior in mice.
- The differential roles of dopamine and noradrenaline in effort/reward trade off. Dopamine and noradrenaline are involved in a variety of functions including reward processing, arousal, attention and sensory processing. Bouret will talk about the comparison of noradrenaline and dopamine in the effort/reward trade off, using neurophysiological and pharmacological tools in monkeys.
- Rapid, cell type specific control of raphe circuits by the lateral hypothalamus. The serotonergic system is involved in many (patho)physiological functions including mood, brain states and sensory processing. Lőrincz will reveal the rules and function of raphe control by lateral hypothalamic projections.