Hungarian Academy of Science Neuroscience Program
Department of Physiology, Anatomy and Neuroscience
University of Szeged
Dr Noémi Holderith Institute of Experimental Medicine Hungarian Academy of Sciences, Budapest, Hungary
“Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles”.
Prof. Huibert Mansvelder
Department of Integrative Neurophysiology,Vrije Universiteit Amsterdam, Netherlands
“Computational properties of human cortical microcircuits”.
Prof. Ed Lein
Allen Institute for Brain Science, Seattle, WA, USA
"Towards a taxonomy of cell types: Molecular and cellular interrogation of human neocortex"
Prof. Christian Steinhäuser
Institut für Zelluläre Neurowissenschaften University of Bonn, Germany
“Altered cellular properties of astrocytes in human temporal lobe epilepsy”.
Prof. Karri Lämsä
Department of Physiology, Anatomy and Neuroscience, University of Szeged, Hungary
“Plasticity in multivesicular synapses controls the human neocortical complex events”.
An increasing number of scientific studies support the idea that evolution has produced functional and structural specializations in the human neocortical and hippocampal microcircuits that do not appear in rodents. However, the vast majority of current cellular neuroscience research, aiming to ultimately understand the human brain function in health and disease, is carried out in model animals such as mice and rats. The microcircuit level specializations evolved in the human phylogeny may be crucial for the specific function of the human brain including abstract mental abilities and capacity of the cortex to perform higher cognitive functions. In addition, human-specific microcircuit features may be substrates for pathological processes resulting in neurological and neuropsychiatric dysfunctions that a mankind as a species is vulnerable to. However, specific features of the human neocortical and hippocampal microcircuits are still poorly known. Although mammalian cortex is evolutionarily conserved, differences occur between species. The topic is gaining increased attention worldwide, and many laboratories in Europe and overseas have initiated investigation of the human and rodent cortical microcircuits in parallel. The results have revealed various differences between our cortical microcircuits and the rodents. In addition to experts in physiological, anatomical or molecular biology research, the results are of general interest for neuroscientists in all fields.